Outliers

Most humans or non humans who get Type 2 diabetes are either pregnant or fat. But what of those who aren't? I see four possibilities.

A. I'm wrong. Pressure isn't a cause.

B. Pressure is the cause for most; something else is the cause for others. For instance, if you ate Shredded Wheat on the third moon after your thirteenth birthday, then danced to a song by Abba, that is why you got diabetes. Actually, I'm joking. Shredded Wheat is good for you.

C. Some animals diagnosed with Type 2 diabetes actually have a mild form of Type 1 diabetes. Instead of the mysterious insulin resistance being the problem, they have damage to the B cells in the Islets of Langerhans in the pancreas, fewer B cells than needed to do the job.

D. The problems that pressure from abdominal fat causes in most animals are brought about some other way in a thin animal with Type 2 diabetes. For instance, if pressure from abdominal fat causes the small offshoots of the inferior pancreaticoduodenal artery to be pinched, and this causes diabetes, pinching of that artery due to clot or genetically programmed malformation will also cause diabetes. (In some people the ligament of treitz, one of the reasons the duodenum hugs the pancreas so tightly, is too short.) In fact, I propose that one way to test my theory - that it's the pressure, not the fat per se, that's causing diabetes - is to put a net around the stomach of a thin animal and pull it over to the animal's left.

BONUS!!! Is "Metabolic Syndrome" an outlier?

I should say not! In fact, it's not an outlier in any theory. Whatever is causing diabetes probably doesn't happen all at once. "Metabolic Syndrome" (as defined here) is, "a condition in which the individual experiences a combination of insulin resistance, elevated cholesterol and hypertension (high blood pressure)." The insulin resistance must be the transitional state from normal to Type 2 diabetic. In the pressure theory, this would come about as pressure worked its magic, probably on the arteries leading to the pancreas. Hardening of the arteries caused by higher cholesterol ought to not only cause high blood pressure, but less blood to the pancreas, less insulin surge, more glucogen in the blood.